Rivastigmine Patch

Pronunciation: RIV-a-STIG-meen
Generic Name: Rivastigmine
Brand Name: Exelon

Rivastigmine Patch is used for:

Treating mild to moderate dementia (eg, impairment of memory or judgement, abstract thinking, changes in personality) in patients with Alzheimer or Parkinson disease.

Rivastigmine Patch is a cholinesterase inhibitor. It works by increasing the amount of a certain substance (acetylcholine) in the brain, which may help reduce symptoms of dementia.

Do NOT use Rivastigmine Patch if:

• you are allergic to any ingredient in Rivastigmine Patch or to carbamate derivatives (eg, meprobamate)


• you are taking another form of rivastigmine (eg, capsules, solution) or another cholinesterase inhibitor (eg, donepezil)

Contact your doctor or health care provider right away if any of these apply to you.

Before using Rivastigmine Patch:

Some medical conditions may interact with Rivastigmine Patch. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

• if you are pregnant, planning to become pregnant, or are breast-feeding


• if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement


• if you have allergies to medicines, foods, or other substances


• if you have a history of kidney or liver problems, certain heart problems (eg, slow or irregular heartbeat, sick sinus syndrome), seizures (eg, epilepsy), stomach or bowel problems (eg, an ulcer), lung or breathing problems (eg, asthma, chronic obstructive pulmonary disease [COPD]), or a urinary blockage (trouble urinating)


• if you have tremors


• if you have dementia or other decreased mental ability that is not caused by Alzheimer or Parkinson disease


• if you are scheduled to have surgery or other medical procedures with general anesthesia


• if you weigh less than 110 pounds (50 kg)

Some MEDICINES MAY INTERACT with Rivastigmine Patch. Tell your health care provider if you are taking any other medicines, especially any of the following:

• Nonsteroidal anti-inflammatory drugs (NSAIDs) (eg, ibuprofen) because the risk of stomach or bowel bleeding may be increased


• Cholinergic agents (eg, bethanechol) or another cholinesterase inhibitor (eg, donepezil) because they may increase the risk of Rivastigmine Patch's side effects


• Anticholinergics (eg, scopolamine) because their effectiveness may be decreased by Rivastigmine Patch

This may not be a complete list of all interactions that may occur. Ask your health care provider if Rivastigmine Patch may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use Rivastigmine Patch:

Use Rivastigmine Patch as directed by your doctor. Check the label on the medicine for exact dosing instructions.

• An extra patient leaflet is available with Rivastigmine Patch. Talk to your pharmacist if you have questions about this information.


• Do not cut or tear the patch. Do not apply a patch if the pouch seal is broken or if the patch has been damaged.


• Apply the patch to the upper or lower back, upper arm, or chest. Use a new application site with each new patch. Do not use the same site within 14 days.


• Apply to dry, intact skin. Do not apply to an area of skin that is hairy, oily, irritated, broken, scarred, or calloused. Do not apply to an area where cream, lotion, or powder has recently been applied. Do not place the patch under tight clothing.


• Do not remove the patch from the sealed pouch until you are ready to apply it.


• To apply the patch, remove the protective liner from one side of the patch. Place the sticky side of the patch to the application site, then remove the second side of the protective liner. Press the patch down firmly until the edges stick well. If you have questions about how to apply the patch, check with your doctor or pharmacist.


• After 24 hours, remove the used patch. Do not touch the sticky side. Fold the patch in half with the sticky sides together. Discard patch out of the reach of children and away from pets.


• Wash your hands thoroughly with soap and water after applying or removing a patch. Do not touch your eyes before you have washed your hands.


• You may wear the patch while bathing, swimming, or showering. Make sure the patch does not come loose during these activities.


• Avoid exposing the application site to direct heat (eg, heating pads or electric blankets, heat lamps, saunas, hot tubs, heated water beds, prolonged direct sunlight) for long periods of time.


• Wear only one patch at a time. Be sure that you remove your old patch before you apply a new one. Change the patch at about the same time each day.


• Do not use bandages or tape to hold down loose patches. Do not reapply patches that have fallen off.


• Continue to use Rivastigmine Patch even if you feel well. Do not miss any doses.


• If your patch falls off or if you miss a dose of Rivastigmine Patch, apply a new patch to a new site, then return to your regular dosing schedule. Do not apply 2 patches at once. Contact your doctor if you miss applying the patch for 3 or more days. Your doctor may need to restart your medicine at a lower dose to avoid side effects.

Ask your health care provider any questions you may have about how to use Rivastigmine Patch.

Important safety information:

• Rivastigmine Patch may cause dizziness or drowsiness. These effects may be worse if you take it with alcohol or certain medicines. Use Rivastigmine Patch with caution. Do not drive or perform other possibly unsafe tasks until you know how you react to it.


• Rivastigmine Patch is for external use only. Do not get it in your mouth.


• Do NOT use more than the recommended dose without checking with your doctor.


• When you begin taking Rivastigmine Patch, your doctor will increase your dose slowly over several months. This may help to decrease the risk of certain side effects (eg, nausea, vomiting, loss of appetite). Carefully follow the dosing schedule prescribed by your doctor.


• Tell your doctor or dentist that you take Rivastigmine Patch before you receive any medical or dental care, emergency care, or surgery.


• Rivastigmine Patch should not be used in CHILDREN; safety and effectiveness in children have not been confirmed.


• PREGNANCY and BREAST-FEEDING: If you become pregnant, contact your doctor. You will need to discuss the benefits and risks of using Rivastigmine Patch while you are pregnant. It is not known if Rivastigmine Patch is found in breast milk. Do not breast-feed while you are using Rivastigmine Patch.

Possible side effects of Rivastigmine Patch:

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Diarrhea; dizziness; headache; loss of appetite; nausea; stomach upset or pain; tiredness; trouble sleeping; vomiting; weakness; weight loss.

Seek medical attention right away if any of these SEVERE side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); anxiety; bloody or black, tarry stools; chest pain; confusion; decreased coordination; decreased, increased, or painful urination; fainting; fever; new or worsening mental or mood changes (eg, depression); new or worsening tremor or uncontrolled muscle movements; new or worsening trouble walking; seizures; severe or persistent diarrhea, nausea, stomach pain, or vomiting; severe or persistent dizziness, tiredness, or weakness; severe or persistent loss of appetite or weight loss; slow or irregular heartbeat; trouble speaking or swallowing; twitching of the face or tongue; vomit that looks like blood or coffee grounds.

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. To report side effects to the appropriate agency, please read the Guide to Reporting Problems to FDA.

See also: Rivastigmine side effects (in more detail)

If OVERDOSE is suspected:

Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center, or emergency room immediately. Symptoms may include fainting; increased saliva production; loss of consciousness; muscle weakness; seizures; severe dizziness; severe nausea or vomiting; severely increased sweating; slow heartbeat; slow or shallow breathing.

Proper storage of Rivastigmine Patch:

Store Rivastigmine Patch at 77 degrees F (25 degrees C). Brief storage at temperatures between 59 and 86 degrees F (15 and 30 degrees C) is permitted. Store away from heat, moisture, and light. Do not store in the bathroom. Keep Rivastigmine Patch out of the reach of children and away from pets.

General information:

• If you have any questions about Rivastigmine Patch, please talk with your doctor, pharmacist, or other health care provider.


• Rivastigmine Patch is to be used only by the patient for whom it is prescribed. Do not share it with other people.


• If your symptoms do not improve or if they become worse, check with your doctor.


• Check with your pharmacist about how to dispose of unused medicine.

This information is a summary only. It does not contain all information about Rivastigmine Patch. If you have questions about the medicine you are taking or would like more information, check with your doctor, pharmacist, or other health care provider.

Issue Date: February 1, 2012

Database Edition 12.1.1.002

Copyright © 2012 Wolters Kluwer Health, Inc.

More Rivastigmine resources

• Rivastigmine Side Effects (in more detail)
• Rivastigmine Use in Pregnancy & Breastfeeding
• Rivastigmine Drug Interactions
• Rivastigmine Support Group
• 6 Reviews for Rivastigmine - Add your own review/rating

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Bexarotene Gel

Pronunciation: beks-AIR-oh-teen
Generic Name: Bexarotene
Brand Name: Targretin

Bexarotene Gel is used for:

Treating skin lesions in patients with cutaneous T-cell lymphoma (CTCL). It may also be used for other conditions as determined by your doctor.

Bexarotene Gel is a retinoid. Exactly how it works is unknown.

Do NOT use Bexarotene Gel if:

• you are allergic to any ingredient in Bexarotene Gel


• you are pregnant or breast-feeding

Contact your doctor or health care provider right away if any of these apply to you.

Before using Bexarotene Gel:

Some medical conditions may interact with Bexarotene Gel. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

• if you are planning to become pregnant


• if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement


• if you have allergies to medicines, foods, or other substances


• if you are allergic to other retinoids (eg, tretinoin)


• if you have liver or kidney problems

Some MEDICINES MAY INTERACT with Bexarotene Gel. Because little, if any, of Bexarotene Gel is absorbed into the blood, the risk of it interacting with another medicine is low.

This may not be a complete list of all interactions that may occur. Ask your health care provider if Bexarotene Gel may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use Bexarotene Gel:

Use Bexarotene Gel as directed by your doctor. Check the label on the medicine for exact dosing instructions.

• Bexarotene Gel is for external use only. Avoid getting Bexarotene Gel in your eyes, nose, or mouth. If you get Bexarotene Gel in your eyes, rinse thoroughly with water.


• Wash your hands before and after using Bexarotene Gel unless your hands are part of the treatment area.


• Apply a generous coating of Bexarotene Gel to the entire lesion. Avoid getting Bexarotene Gel on the healthy skin around the lesions. Allow Bexarotene Gel to dry before covering it with cloth.


• Do not bandage or wrap Bexarotene Gel unless instructed to do so by your doctor.


• Continue to use Bexarotene Gel even if you feel well. Do not miss any doses.


• If you miss a dose of Bexarotene Gel, use it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not use 2 doses at once.

Ask your health care provider any questions you may have about how to use Bexarotene Gel.

Important safety information:

• Bexarotene Gel may cause increased sensitivity to the sun. Avoid exposure to the sun, sunlamps, or tanning booths until you know how you react to Bexarotene Gel. Use a sunscreen or wear protective clothing if you must be outside for a prolonged period.


• Do not use products that contain DEET (eg, insect repellant) while you are using Bexarotene Gel.


• Do not exceed the recommended dose or use Bexarotene Gel for longer than prescribed without checking with your doctor.


• Talk to your doctor before taking vitamin A supplements or multivitamins that contain vitamin A.


• During sexual intercourse with a woman who may become pregnant, men taking Bexarotene Gel should use a condom during treatment with Bexarotene Gel and for at least 30 days after it is stopped.


• Women using Bexarotene Gel must have a negative pregnancy test within 1 week prior to beginning therapy with Bexarotene Gel, and each month after that until therapy is finished. Begin therapy with Bexarotene Gel on the second and third day of a normal menstrual period. Use 2 effective forms of birth control during treatment with Bexarotene Gel and for at least 30 days after it is stopped.


• Bexarotene Gel may be harmful if swallowed. If you or someone you know may have taken Bexarotene Gel by mouth, contact your local poison control center or emergency room immediately.


• Use Bexarotene Gel with extreme caution in CHILDREN. Safety and effectiveness have not been confirmed.


• PREGNANCY and BREAST-FEEDING: Do not use Bexarotene Gel if you are pregnant. If you suspect that you could be pregnant, contact your doctor immediately. It is unknown if this excreted in breast milk. Do not breast-feed while you are using Bexarotene Gel.

Possible side effects of Bexarotene Gel:

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Headache; pain or itching at the application site.

Seek medical attention right away if any of these SEVERE side effects occur:

Severe allergic reactions (rash; hives; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); fever, chills, or sore throat; irritation at the application site; numbness or tingling of the skin; swelling.

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. To report side effects to the appropriate agency, please read the Guide to Reporting Problems to FDA.

If OVERDOSE is suspected:

Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center (http://www.aapcc.org ), or emergency room immediately.

Proper storage of Bexarotene Gel:

Store Bexarotene Gel at 77 degrees F (25 degrees C). Brief storage at temperature between 59 and 86 degrees F (15 and 30 degrees C) is permitted. Store away from heat, moisture, and light. Do not store in the bathroom. Keep Bexarotene Gel out of the reach of children and away from pets.

General information:

• If you have any questions about Bexarotene Gel, please talk with your doctor, pharmacist, or other health care provider.


• Bexarotene Gel is to be used only by the patient for whom it is prescribed. Do not share it with other people.


• If your symptoms do not improve or if they become worse, check with your doctor.


• Check with your pharmacist about how to dispose of unused medicine.

This information is a summary only. It does not contain all information about Bexarotene Gel. If you have questions about the medicine you are taking or would like more information, check with your doctor, pharmacist, or other health care provider.

Issue Date: February 1, 2012

Database Edition 12.1.1.002

Copyright © 2012 Wolters Kluwer Health, Inc.

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